PLATFORM 01
cPhageBank Building
Natural Phages
High-performance lytic phages are screened and isolated from natural sources. The cPhageBank comprises phages with diverse genetic backgrounds, distinct lysis profiles, and varied bacterial-killing mechanisms, collectively forming a broad-spectrum phage resource that includes phage isolates, their genome sequences, and phage–bacteria interaction networks.
Synthetic Phages
Through the modification of natural phages and de novo synthesis techniques, engineered phages with broad lytic spectra, enhanced lytic potency, and a reduced propensity to induce bacterial resistance are constructed to overcome the bottlenecks of natural phages—namely, narrow killing spectra and bacterial anti-phage resistance.
PLATFORM 02
Intelligent Phage Susceptibility Testing
Plaque Assay + Intelligent Reporting
High-throughput screening of 96 phages on one agar plate, with image-based intelligent recognition of lytic phages for automatic scoring and reporting of cphage library screening result.
Killing-curve Assay + Dynamic Interaction Report
High-throughput screening of 96/384 phages on one multi-well plate, with real-time bacterial growth monitoring to assess phage lytic power and bacterial anti-phage resistance for automatic scoring and reporting.
PLATFORM 03
Synthetic Phages
Broadening Lysis Spectrum
By replacing, modifying, or synthesizing receptor-binding ligand of phages (such as tail fibers and/or tail-spike proteins) to broaden their receptor-binding capacities, addressing the narrow lytic spectrum of natural phages.
Enhancing Lytic Power
By enhancing phage bactericidal components and weakening bacterial resistance elements, addressing the issue of bacterial resistance to natural phages.
Engineering · Synthesis · Lytic spectrum & activity