PLATFORM 01
cPhageBank Building
Minimal Library + Comprehensive Database
For each target bacterium, we rapidly build a minimal phage library covering its prevalent strains, together with a comprehensive database of whole-genome sequences of phages and bacteria and their antagonistic relationships.
Natural Isolation + Engineering
The library combines high-performance lytic phages screened and isolated from nature with engineered phages purpose-constructed through gene editing, de novo synthesis and other technologies.
PLATFORM 02
Intelligent Phage Susceptibility Testing
Conventional PST + Intelligent Reporting
High-throughput screening of 96 phages per double-layer plate, with intelligent image recognition to identify lytic phages for automatic scoring and reporting of lytic activity; high-throughput screening of 96/384 phages per microplate, with real-time monitoring to assess phage lytic power and bacterial tolerance for automatic scoring and reporting.
Virtual PST
Based on the species, distinctive phenotypes and epidemiological characteristics of the target bacterium, we intelligently predict its best-matching type and select a targeted phage formulation accordingly; from the genomic sequence of the target bacterium, we intelligently predict which phages in the library can lyse it.
PLATFORM 03
Gene Editing
Production Host Engineering
The production host is engineered by knocking out genetic elements with potential impact on product safety to improve safety, and knocking out phage-resistance elements to increase phage yield.
Phage Engineering
Phages are engineered by replacing, modifying or synthesizing tail fiber proteins to broaden the receptor types they can bind, overcoming the narrow host coverage of natural phages, and by strengthening phage bactericidal elements while weakening bacterial counter-defense elements, overcoming bacterial tolerance.
Engineering · Synthesis · Lytic spectrum & activity